Topical nitrogen mustard ointment with occlusion for Langerhans' cell histiocytosis of the scalp.

Abstract

BACKGROUND:

Topical nitrogen mustard solution has been used as an effective alternative to corticosteroids for the treatment of cutaneous eruptions of Langerhans' cell histiocytosis (LCH). When used as an ointment under occlusion, nitrogen mustard may still be effective and possess less risk of unwanted side effects.

METHODS:

A patient with scalp LCH was treated topically with nitrogen mustard ointment 0.01% under occlusion.

RESULTS:

The lesions cleared in 3 weeks without irritation.

CONCLUSION:

Topical nitrogen mustard ointment 0.01% under occlusion is a well-tolerated, non-irritating treatment for scalp LCH.

• Authors: J R Treat, K R Suchin, W D James
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 14 Issue 1 Pg. 46-7 (Jan 2003) ISSN: 0954-6634 [Print] England
• PMID: 12745855 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Ointments
• Mechlorethamine

Topics

• Administration, Cutaneous
• Adult
• Antineoplastic Agents, Alkylating (administration & dosage, therapeutic use)
• Histiocytosis, Langerhans-Cell (drug therapy)
• Humans
• Male
• Mechlorethamine (administration & dosage, therapeutic use)
• Ointments
• Scalp Dermatoses (drug therapy)