A lipoprotein lipase-promoting agent, NO-1886, improves glucose and lipid metabolism in high fat, high sucrose-fed New Zealand white rabbits.

Abstract

The synthetic compound NO-1886 is a lipoprotein lipase activator that lowers plasma triglycerides and elevates high-density lipoprotein cholesterol (HDL-C). Recently, the authors found that NO-1886 also had an action of reducing plasma glucose in high-fat/high-sucrose diet-induced diabetic rabbits. In the current study, we investigated the effects of NO-1886 on insulin resistance and beta-cell function in rabbits. Our results showed that high-fat/high-sucrose feeding increased plasma triglyceride, free fatty acid (FFA), and glucose levels and decreased HDL-C level. This diet also induced insulin resistance and impairment of acute insulin response to glucose loading. Supplementing 1% NO-1886 into the high-fat/high-sucrose diet resulted in decreased plasma triglyceride, FFA, and glucose levels and increased HDL-C level. The authors also found a clear increased glucose clearance and a protected acute insulin response to intravenous glucose loading by NO-1886 supplementation. These data suggest that NO-1886 suppresses the elevation of blood glucose in rabbits induced by feeding a high-fat/high-sucrose diet, probably through controlling lipid metabolism and improving insulin resistance.

• Authors: Weidong Yin, Zhonghua Yuan, Kazuhiko Tsutsumi, Yuxiang Xie, Qiuju Zhang, Zongbao Wang, Guoxiang Fu, Guang Long, Yongzong Yang
• Journal: International journal of experimental diabesity research (Int J Exp Diabesity Res) 2003 Jan-Mar Vol. 4 Issue 1 Pg. 27-34 United States
• PMID: 12745668 (Publication Type: Journal Article)
• Copyright: Copyright 2003 Taylor and Francis

Chemical References

• Benzamides
• Blood Glucose
• Dietary Fats
• Dietary Sucrose
• Hypolipidemic Agents
• Organophosphorus Compounds
• 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide
• Lipoprotein Lipase

Topics

• Abdomen
• Adipose Tissue (drug effects, metabolism)
• Animals
• Benzamides (pharmacology)
• Blood Glucose (drug effects, metabolism)
• Dietary Fats (pharmacology)
• Dietary Sucrose (pharmacology)
• Enzyme Activation
• Hypolipidemic Agents (pharmacology)
• Lipoprotein Lipase (drug effects, metabolism)
• Male
• Models, Animal
• Organophosphorus Compounds (pharmacology)
• Rabbits
• Time Factors