Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride.

In our study, the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases of inflammation, respectively. Their effects on vascular permeability were also tested by hyaluronidase-induced capillary permeability. C1 decreased the carrageenan-induced paw edema 61.98, 80.84, and 90.32% at 50, 100, and 200mgkg(-1) doses, respectively, while this decrease was 89.93% by indomethacin at 20mgkg(-1) dose. Antiproliferative effects of C1 at 100mgkg(-1) and indomethacinin at 20mgkg(-1) doses were 46.1 and 43.1%, respectively, in cotton pellet test. C1 and indomethacin both significantly inhibited the hyaluronidase-induced increase in capillary permeability.
AuthorsHalis Suleyman, Halise Inci Gul, Mehmet Asoglu
JournalPharmacological research (Pharmacol Res) Vol. 47 Issue 6 Pg. 471-5 (Jun 2003) ISSN: 1043-6618 [Print] England
PMID12741999 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride
  • Anti-Inflammatory Agents, Non-Steroidal
  • Piperidines
  • Carrageenan
  • Hyaluronoglucosaminidase
  • Indomethacin
  • Analysis of Variance
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Capillary Permeability (drug effects)
  • Carrageenan
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Edema (chemically induced, drug therapy)
  • Granuloma, Foreign-Body (drug therapy, physiopathology)
  • Hyaluronoglucosaminidase (pharmacology)
  • Indomethacin (pharmacology)
  • Inflammation (chemically induced, drug therapy, physiopathology)
  • Male
  • Piperidines (pharmacology)
  • Rats
  • Rats, Wistar

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