Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating.

RESEARCH METHODS AND PROCEDURES:

Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout.

RESULTS:

Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine.

DISCUSSION:

Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.

• Authors: James E Mitchell, Blake A Gosnell, James L Roerig, Martina de Zwaan, Stephen A Wonderlich, Ross D Crosby, Melissa A Burgard, Beth N Wambach
• Journal: Obesity research (Obes Res) Vol. 11 Issue 5 Pg. 599-602 (May 2003) ISSN: 1071-7323 [Print] United States
• PMID: 12740447 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Appetite Depressants
• Cyclobutanes
• sibutramine

Topics

• Adult
• Appetite Depressants (pharmacology)
• Bulimia (drug therapy)
• Cross-Over Studies
• Cyclobutanes (pharmacology)
• Double-Blind Method
• Eating (drug effects)
• Female
• Humans
• Hunger (drug effects)
• Male
• Middle Aged
• Satiety Response (drug effects)
• Weight Loss (drug effects)