Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum.

Abstract

A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH(2)Cl(2) fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-alpha-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-alpha secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.

• Authors: Xing Fu Cai, Guanghai Shen, Nguyen Tien Dat, Ok Hwa Kang, Jin A Kim, Young Mi Lee, Jung Joon Lee, Young Ho Kim
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 51 Issue 5 Pg. 605-7 (May 2003) ISSN: 0009-2363 [Print] Japan
• PMID: 12736467 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Abietanes
• Diterpenes
• Interleukin-8
• Tumor Necrosis Factor-alpha
• acanthokoreoic acid A
• pimarane
• Trypsin

Topics

• Abietanes
• Chromatography, High Pressure Liquid
• Diterpenes (isolation & purification, pharmacology)
• Eleutherococcus (chemistry)
• Enzyme-Linked Immunosorbent Assay
• HT29 Cells
• Humans
• Interleukin-8 (antagonists & inhibitors, metabolism)
• Korea
• Magnetic Resonance Spectroscopy
• Mast Cells (metabolism)
• Plant Roots (chemistry)
• Spectrometry, Mass, Fast Atom Bombardment
• Spectrophotometry, Infrared
• Trypsin (chemistry)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, metabolism)