Acute myelogenous leukemia M5b developed during clinical remission of Castleman disease.

Abstract

Castleman disease (CD) is a rare heterogeneous lymphoproliferative disease characterized by clinical symptoms due to an excess of interleukin-6 (IL-6) or IL-6-like activity. We describe the first case of CD associated with acute myelogenous leukemia (AML). A 55-year-old man presented with skin rash on his face and multiple cervical lymphadenopathy. The results of examination of his lymph node biopsy specimen led to a diagnosis of CD. The symptoms resolved after the administration of prednisolone. Three years after the onset of CD, the patient's white blood cell count had increased to 63.4 x 10(9)/L. His bone marrow aspirate showed that approximately 80% of cells were leukemic, including well-differentiated monocytic cells A diagnosis of AML M5b was made. The patient died of invasive pulmonary aspergillosis after chemotherapy.

• Authors: Akira Tomonari, Naoki Shirafuji, Arinobu Tojo, Tohru Iseki, Jun Ooi, Itaru Komiya, Kenzaburo Tani, Shigetaka Asano
• Journal: International journal of hematology (Int J Hematol) Vol. 77 Issue 3 Pg. 274-6 (Apr 2003) ISSN: 0925-5710 [Print] Japan
• PMID: 12731671 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Prednisolone

Topics

• Antineoplastic Agents, Hormonal (therapeutic use)
• Bone Marrow (pathology)
• Castleman Disease (complications, drug therapy, pathology)
• Fatal Outcome
• Humans
• Leukemia, Monocytic, Acute (diagnosis, drug therapy, etiology)
• Lymph Nodes (pathology)
• Male
• Middle Aged
• Prednisolone (therapeutic use)
• Remission Induction