Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise.

Abstract

OBJECTIVE:

To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus.

METHODS:

Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention.

RESULTS:

Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi2=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise.

CONCLUSION:

These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus.

• Authors: C M Tench, J McCarthy, I McCurdie, P D White, D P D'Cruz
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 42 Issue 9 Pg. 1050-4 (Sep 2003) ISSN: 1462-0324 [Print] England
• PMID: 12730519 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Exercise Therapy
• Fatigue (etiology, physiopathology, rehabilitation)
• Female
• Follow-Up Studies
• Humans
• Lupus Erythematosus, Systemic (complications, physiopathology)
• Middle Aged
• Patient Compliance
• Patient Dropouts
• Patient Satisfaction
• Relaxation Therapy
• Treatment Outcome