Tumor necrosis factor-alpha production-regulating activity of phthalimide derivatives in genetically modified murine melanoma cells B78H1.

Abstract	The effect of imides, monothioimides, trimellitimides, as well as 5'-deoxy-5'-phthaloylamino-derivatives of azidothymidine on tumor necrosis factor-alpha (TNF-alpha) production by genetically modified murine B78H1 melanoma cells transduced with the gene for human TNF-alpha (B78/TNF) was investigated. It was found that N-(adamant-1-yl)monothiophthalimide (1e) and N-(adamant-2-yl)-monothiophthalimide (1f) showed over 200% enhancing of TNF-alpha production while some of imides were inhibitors.
Authors	Andrzej Orzeszko, Witold Lasek, Tomasz Switaj, Magdalena Stoksik, Beata Kamińska
Journal	Farmaco (Societa chimica italiana : 1989) (Farmaco) Vol. 58 Issue 5 Pg. 371-6 (May 2003) ISSN: 0014-827X [Print] France
PMID	12729831 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Phthalimides Tumor Necrosis Factor-alpha Zidovudine
Topics	Animals Drug Design Melanoma Mice Phthalimides (chemical synthesis, pharmacology) Tumor Cells, Cultured Tumor Necrosis Factor-alpha (biosynthesis) Zidovudine (analogs & derivatives, chemical synthesis, pharmacology)

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