Abstract |
The aim of the study was to examine the influence of the blockade of group I metabotropic glutamate receptors (mGluRs) on the haloperidol-induced catalepsy and proenkephalin mRNA expression in the rat striatum. Bilateral, intrastriatal injection of AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid, 3-15 microg/0.5 microl), a selective antagonist of group I mGluRs, inhibited catalepsy induced by haloperidol (0.5 mg/kg i.p.). Repeated intrastriatal AIDA administrations (3 x 15 microg/0.5 microl, 3 h apart) counteracted the haloperidol-induced (3 x 1.5 mg/kg s.c., 3 h apart) increase in the proenkephalin mRNA expression in that structure. The present study indicates that the blockade of the striatal group I mGluRs may inhibit parkinsonian akinesia by normalizing the function of the striopallidal pathway.
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Authors | Krystyna Ossowska, Jadwiga Wardas, Małgorzata Pietraszek, Jolanta Konieczny, Stanisław Wolfarth |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 342
Issue 1-2
Pg. 21-4
(May 15 2003)
ISSN: 0304-3940 [Print] Ireland |
PMID | 12727308
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Antagonists
- Enkephalins
- Protein Precursors
- RNA, Messenger
- Receptors, Metabotropic Glutamate
- metabotropic glutamate receptor type 1
- proenkephalin
- Haloperidol
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Topics |
- Animals
- Cataplexy
(chemically induced, drug therapy, metabolism)
- Corpus Striatum
(drug effects, metabolism)
- Dopamine Antagonists
- Enkephalins
(drug effects, metabolism)
- Globus Pallidus
(drug effects, metabolism)
- Haloperidol
- Male
- Neural Pathways
(metabolism)
- Parkinson Disease
(metabolism)
- Protein Precursors
(drug effects, metabolism)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Wistar
- Receptors, Metabotropic Glutamate
(antagonists & inhibitors, metabolism)
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