[A study on the expression of VEGF in the blunt injury of rat's skin].

Abstract

OBJECTIVE:

To evaluate changes of VEGF in skin after blunt injury.

METHODS:

The rats of injury groups were subjected to skin blunt injury by free-falling iron hammer. The samples taken at 1 h, 3 h, 6 h, 12 h, 1 d, 3 d, 5 d, 7 d, 9 d after injury were studied by immunohistochemistry and MIAS image analysis system.

RESULTS:

In the skin of normal control group the expression level of VEGF was low. The increase of VEGF could be observed at 1 day after injury, reached peak at 7 days and declined at 9 days.

CONCLUSION:

Blunt injury in the skin could induce the expression of the VEGF. Moreover, the change pattern of VEGF level was quite regular with time and could be used to estimate the time after skin injury.

• Authors: Mei Li, Pei-jun Huang, Min Liu
• Journal: Fa yi xue za zhi (Fa Yi Xue Za Zhi) Vol. 19 Issue 1 Pg. 13-5 ( 2003) ISSN: 1004-5619 [Print] China
• PMID: 12725159 (Publication Type: English Abstract, Journal Article)

Chemical References

• Endothelial Growth Factors
• Intercellular Signaling Peptides and Proteins
• Lymphokines
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors

Topics

• Animals
• Endothelial Growth Factors (metabolism)
• Female
• Forensic Medicine
• Intercellular Signaling Peptides and Proteins (metabolism)
• Lymphokines (metabolism)
• Male
• Rats
• Rats, Sprague-Dawley
• Skin (injuries, metabolism)
• Time Factors
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors
• Wounds, Nonpenetrating (metabolism)