[Effects of tea on aberrant crypt foci and colorectal tumors in rats].

Abstract

The present study was designed to investigate the chemopreventive effects of green tea and tea pigments (the main component of black tea) on 1,2-dimethylhydrazine (DMH)-induced rat colorectal carcinogenesis. Compared with the positive control group, green tea and tea pigments groups had less numbers of aberrant crypt foci (ACF) (P < 0.01) at the end of week 16. At the end of week 32, all rats in the positive control group developed colorectal tumors with an average of 2.6 tumors per rat, and a mean volume of 294.7 mm3 per tumor, while in the groups drinking green tea and tea pigments, the average numbers of colorectal tumors per rat were only 47.1% and 43.1% of controls respectively, and the mean tumor volume was inhibited by 77.1% and 68.1% respectively. It was concluded that tea pigments had a chemopreventive effect on colorectal tumor and ACF formation can be used as a useful intermediate end point to study chemopreventive effects on colorectal cancer.

• Authors: X Jia, W Wang, W Cui, C Han
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 29 Issue 1 Pg. 54-6 (Jan 30 2000) ISSN: 1000-8020 [Print] China
• PMID: 12725046 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Pigments, Biological
• Plant Extracts
• Tea
• 1,2-Dimethylhydrazine

Topics

• 1,2-Dimethylhydrazine
• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Colon (pathology)
• Colorectal Neoplasms (chemically induced, pathology)
• Pigments, Biological (pharmacology)
• Plant Extracts (pharmacology)
• Precancerous Conditions (chemically induced, pathology)
• Rats
• Rats, Wistar
• Tea (chemistry)