Action of tilidine hydrochloride and morphine hydrochloride on ventilatory control in normal subjects.

Abstract

The action of tilidine hydrochloride and morphine hydrochloride on the ventilatory response to inhaled carbon dioxide has been assessed in 10 normal volunteers. In doses of 50 mg and 100 mg given intravenously, tilidine hydrochloride induced less respiratory depression than 10 mg of morphine given intravenously. Side effects were not different or troublesome with either drug. Depending on its relative pain-relieving property, tilidine hydrochloride may have advantages over morphine as an analgesic.

• Authors: N Maranetra, M C Pain
• Journal: The Medical journal of Australia (Med J Aust) Vol. 1 Issue 12 Pg. 397-8 (Mar 20 1976) ISSN: 0025-729X [Print] Australia
• PMID: 1272123 (Publication Type: Journal Article)

Chemical References

• Cyclohexanecarboxylic Acids
• Carbon Dioxide
• Morphine
• Tilidine

Topics

• Adult
• Carbon Dioxide
• Cyclohexanecarboxylic Acids (pharmacology)
• Female
• Humans
• Male
• Morphine (adverse effects, pharmacology)
• Respiration (drug effects)
• Tilidine (adverse effects, pharmacology)