HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats.

Abstract
Reactive oxygen species have been implicated in the pathophysiology of renal ischemia reperfusion (I/R) injury. The pineal secretory product melatonin is known to be a potent free radical scavenger and antioxidant. This study was designed to investigate the effects of physiological and pharmacological concentrations of melatonin on I/R injury. Rats were pinealectomized (Px) or sham-operated (control) 2 months before the I/R studies. There were eight groups of eight rats each. After a right nephrectomy to produce damage, left renal vessels were occluded for 60 min, followed by 24 h reperfusion, in rats. Malondialdehyde (MDA) levels resulting from I/R were significantly higher in the pinealectomized rats than in the control group. Melatonin administration (4 mg kg(-1) i.p. either before ischemia or reperfusion) to Px and sham-operated rats significantly reduced the MDA values and returned them to the control values. Morphological changes in the groups were similar to the MDA levels. Serum levels of blood urea nitrogen and creatine were unchanged. These results suggest that physiological and pharmacological melatonin concentrations are important for the reduction of I/R-induced damage. We also demonstrated that melatonin, even when administrated just before reperfusion, had a protective effect on I/R injury. It would seem valuable to test melatonin in clinical trials for the prevention of possible I/R injury.
AuthorsEngin Sahna, Hakan Parlakpinar, Feral Ozturk, Yilmaz Cigremis, Ahmet Acet
JournalUrological research (Urol Res) Vol. 31 Issue 3 Pg. 188-93 (Jul 2003) ISSN: 0300-5623 [Print] Germany
PMID12719947 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Free Radical Scavengers
  • Malondialdehyde
  • Melatonin
  • Creatine
Topics
  • Animals
  • Antioxidants (administration & dosage)
  • Blood Urea Nitrogen
  • Creatine (blood)
  • Dose-Response Relationship, Drug
  • Free Radical Scavengers (administration & dosage)
  • Kidney (metabolism, pathology)
  • Male
  • Malondialdehyde (metabolism)
  • Melatonin (administration & dosage)
  • Osmolar Concentration
  • Rats
  • Rats, Wistar
  • Renal Circulation
  • Reperfusion Injury (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: