Abstract | BACKGROUND: Salmonella species now represent a leading cause of Gram-negative bacterial meningitis in the developing world. Various drugs have been used for the treatment of Salmonella meningitis over the past decades, but mortality, neurologic sequelae and relapse rates remain high. In this report we describe two children aged 8 and 9 months who presented within a week to our hospital with Salmonella meningitis. They were treated with penicillin and chloramphenicol but progressed rapidly to death within 48 h. AIM: The aim of this article is to review all published English literature on the treatment of Salmonella meningitis and identify the best drug option for its treatment. This was done by comparing the outcomes such as cure, failure, relapse, and death rates. METHOD: A Medline electronic search was carried out to find and retrieve articles that have been published since 1987, when the last review of Salmonella meningitis was done. RESULTS: CONCLUSION:
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Authors | Alex Owusu-Ofori, W Michael Scheld |
Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
(Int J Infect Dis)
Vol. 7
Issue 1
Pg. 53-60
(Mar 2003)
ISSN: 1201-9712 [Print] Canada |
PMID | 12718811
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
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Topics |
- Anti-Infective Agents
(therapeutic use)
- Fatal Outcome
- Female
- Humans
- Infant
- Male
- Meningitis, Bacterial
(drug therapy, microbiology, mortality)
- Salmonella Infections
(drug therapy, microbiology, mortality)
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