Abstract | INTRODUCTION: It has been reported that angiogenic factors play an important role in proliferation and metastasis in various cancers.AIMTo investigate the expression of angiogenic factors and microvessel density (MVD) in pancreatic ductal carcinoma and to examine the correlations among expression of angiogenic factors, clinicopathologic parameters, and clinical prognosis. METHODOLOGY: RESULTS: Immunostaining demonstrated that 70.8% of pancreatic ductal carcinomas were positive for VEGF, 60.9% for FGF-2, and 57.2% for PD-ECGF. A significant correlation was observed between VEGF expression and MVD (p < 0.05) but not between FGF-2 or PD-ECGF and MVD. Although the expression of each angiogenic factor had no correlation with clinicopathologic features, the patients with tumors that showed high expression of VEGF and FGF-2 had significantly shorter survival times than those with low or no such expression (p < 0.05). CONCLUSIONS:
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Authors | Kenichi Kuwahara, Tamito Sasaki, Yukio Kuwada, Masateru Murakami, Souichirou Yamasaki, Kazuaki Chayama |
Journal | Pancreas
(Pancreas)
Vol. 26
Issue 4
Pg. 344-9
(May 2003)
ISSN: 1536-4828 [Electronic] United States |
PMID | 12717266
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inducing Agents
- Antigens, CD34
- Vascular Endothelial Growth Factor A
- Fibroblast Growth Factor 2
- Thymidine Phosphorylase
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Topics |
- Angiogenesis Inducing Agents
(analysis)
- Antigens, CD34
(analysis)
- Blood Vessels
(chemistry, pathology)
- Carcinoma, Pancreatic Ductal
(blood supply, metabolism, pathology)
- Fibroblast Growth Factor 2
(analysis)
- Humans
- Immunohistochemistry
- Pancreatic Neoplasms
(blood supply, metabolism, pathology)
- Statistics as Topic
- Survival Analysis
- Thymidine Phosphorylase
(analysis)
- Vascular Endothelial Growth Factor A
(analysis)
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