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[Therapeutic possibilities for polyomavirus infections in renal transplantation].

Abstract
TO IMPROVE THERAPEUTIC MANAGEMENT: The aim is the early detection of polyomavirus infection, before the onset of tubulo-interstitial nephritic lesions, and to reduce viral replication. AT THE STAGE OF POLYOMAVIRUS INFECTION: Treatment relies on the reduction of immunosuppression. Efficacy is controlled by monitoring the decoy cells in the urine and the detection and quantification of the DNA of polyomaviruses in the plasma and urine. AT THE STAGE OF POLYOMAVIRUS DISEASE: The aim is to reduce the viral replication by further decreasing immunosuppression to stabilize renal function and avoid graft rejection. When signs of rejection and viral infection co-exist, cidofovir could be a therapeutic alternative. However, the use of cidofovir remains in the field of clinical research and requires the further development of therapeutic protocols.
AuthorsBruno Hurault de Ligny, Michel Godin, Thierry Lobbedez, Isabelle Etienne, Wael El Haggan, Myriam Pujo, Jean-Philippe Ryckelynck
JournalPresse medicale (Paris, France : 1983) (Presse Med) Vol. 32 Issue 14 Pg. 667-8 (Apr 12 2003) ISSN: 0755-4982 [Print] France
Vernacular TitlePossibilités thérapeutiques des infections à polyomavirus humains en transplantation rénale.
PMID12714908 (Publication Type: Journal Article, Review)
Chemical References
  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • Cidofovir
Topics
  • Antiviral Agents (therapeutic use)
  • BK Virus (pathogenicity)
  • Cidofovir
  • Cytosine (analogs & derivatives, therapeutic use)
  • Humans
  • JC Virus (pathogenicity)
  • Kidney Transplantation (adverse effects)
  • Nephritis, Interstitial (drug therapy, etiology, virology)
  • Organophosphonates
  • Organophosphorus Compounds (therapeutic use)
  • Polyomavirus Infections (drug therapy, etiology)
  • Virus Replication

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