[Long-term results of treatment of chronic B-cell lymphoid leukocytes in persons who participated in the elimination of the effects of the nuclear accident at the Chernobyl nuclear station].

Abstract

Clinical-and-hematological characteristics are presented of B-cell chronic lymphoid leukosis in those persons who took part in the elimination of the effects of the Chornobyl accident in the remote period. Results are highlighted of treatment of 16 patients with making use of different chemical drug preparations. Employment of fludarabin and cyclophosphan combined in treatment of the medical condition in question has been shown to promote long-term complete and partial remissions in a major proportion of patients, which effect was not achievable with standard means of remediation. A side effect of fludarabin was leukocytopenia that in the presence of changed immunity threatened the patients with development and exacerbation of infections complications. Use of manax and erbisol moderated the immunosuppressive and toxic action of fludarabin, due to which fact infectious complications and drug-induced hepatitis have came to be less common, the patients' quality of life gotten better.

• Authors: V I Klymenko, D A Bazyka, O M Polishchuk, I A Kriachok, Z V Martina, T V Kadnikova, S V Klymenko
• Journal: Likars'ka sprava (Lik Sprava) 2003 Jan-Feb Issue 1 Pg. 18-20 ISSN: 1019-5297 [Print] Ukraine
• Vernacular Title: Rezul'taty likuvannia khronichnoho B-klitynnoho limfoleĭkozu v uchasnykiv likvidatsiï naslidkiv avariï na ChAES u viddalenomu periodi.
• PMID: 12712601 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biological Factors
• erbisol
• Cyclophosphamide
• Vidarabine
• fludarabine

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biological Factors (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Hepatitis (complications)
• Humans
• Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy, etiology)
• Leukemia, Radiation-Induced (drug therapy)
• Leukopenia (chemically induced)
• Male
• Middle Aged
• Quality of Life
• Radioactive Hazard Release
• Remission Induction
• Time Factors
• Treatment Outcome
• Ukraine
• Vidarabine (adverse effects, analogs & derivatives, therapeutic use)