An antiviral meliacarpin from leaves of Melia azedarach L.

Abstract

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.

• Authors: Laura E Alché, Guillermo Assad Ferek, Milena Meo, Celia E Coto, Marta S Maier
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 2003 Mar-Apr Vol. 58 Issue 3-4 Pg. 215-9 ISSN: 0939-5075 [Print] Germany
• PMID: 12710731 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1-cinnamoyl-3,11-dihydroxymeliacarpin
• Antiviral Agents
• Limonins
• Monoterpenes

Topics

• Antiviral Agents (chemistry, isolation & purification, pharmacology)
• Biological Assay
• Herpesvirus 1, Human (drug effects)
• Limonins (chemistry, isolation & purification, pharmacology)
• Melia azedarach (chemistry)
• Microbial Sensitivity Tests
• Monoterpenes (chemistry, isolation & purification, pharmacology)
• Plant Leaves (chemistry)
• Vesicular stomatitis Indiana virus (drug effects)