Abstract |
Paroxysmal nocturnal hemoglobinuria (PNH) is associated with a high risk of thrombosis, particularly in the peripheral, cerebral, and abdominal veins. We report a patient with an occlusion of the hepatic veins and a slit shape narrowing of the cava inferior consistent with the Budd-Chiari syndrome in whom intravenous fibrinolytic therapy with recombinant tissue plasminogen activator (rt-PA) was applied. Systemic rt-PA was given in a dose of 25 mg rt-PA over 3 h and 25 mg rt-PA as constant intravenous infusion over the next 21 h leading to an incomplete recanalization. The same protocol was applied again 2 days later, resulting in a complete recanalization of the hepatic veins and the vena cava inferior. Our case shows that exclusive systemic application of rt-PA can result in full anatomic and clinical restoration.
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Authors | A C Hauser, A Brichta, I Pabinger-Fasching, U Jäger |
Journal | Annals of hematology
(Ann Hematol)
Vol. 82
Issue 5
Pg. 299-302
(May 2003)
ISSN: 0939-5555 [Print] Germany |
PMID | 12707719
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Tissue Plasminogen Activator
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Topics |
- Adult
- Body Weight
(drug effects)
- Budd-Chiari Syndrome
(diagnostic imaging, drug therapy, etiology)
- Female
- Hemoglobinuria, Paroxysmal
(complications, drug therapy)
- Humans
- Infusions, Intravenous
- Thrombolytic Therapy
(methods)
- Tissue Plasminogen Activator
(administration & dosage)
- Treatment Outcome
- Ultrasonography
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