| Abstract | We report a case of bullous pemphigoid successfully treated with double filtration plasmapheresis. The changes in titers of circulating autoantibodies were assessed by immunoblotting and enzyme-linked immunosorbent assay (ELISA) using a recombinant protein of the non-collagenous 16a (NC16a) domain of the 180 kDa bullous pemphigoid antigen (BP180). The ELISA was shown to be more sensitive in detecting disease-specific antoantibodies in the bullous pemphigoid sera. The reduction of titers of circulating autoantibodies in the sera correlated well with the decrease in the disease activity in both the first and second rounds of plasmapheresis treatment in this case. |
| Authors | Jee Bum Lee, Takeaki Fumimori, Koichiro Kurose, Osamu Mori, Takashi Hashimoto
(Affiliation: Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan.)
|
| Journal | The Journal of dermatology
(J Dermatol)
Vol. 30
Issue 4
Pg. 326-31
(Apr 2003)
ISSN: 0385-2407 Japan |
| PMID | 12707470
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Autoantibodies
- Autoantigens
- Carrier Proteins
- Cytoskeletal Proteins
- DST protein, human
- Nerve Tissue Proteins
- Non-Fibrillar Collagens
- collagen type XVII
- Collagen
|
| Topics |
- Autoantibodies
(analysis)
- Autoantigens
(analysis)
- Carrier Proteins
- Collagen
(analysis)
- Cytoskeletal Proteins
- Enzyme-Linked Immunosorbent Assay
- Follow-Up Studies
- Humans
- Immunoblotting
(methods)
- Male
- Middle Aged
- Nerve Tissue Proteins
- Non-Fibrillar Collagens
- Pemphigoid, Bullous
(immunology, therapy)
- Plasmapheresis
(methods)
- Sensitivity and Specificity
- Severity of Illness Index
- Treatment Outcome
|
