Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1.

Abstract

CTL play a major role in immunity to HSV type 1, but little is known about the priming process. In this study, we have examined the class I-restricted presentation of an immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have found that the only cell types capable of presenting this determinant in draining popliteal lymph nodes within the first 3 days after infection are the CD11c(+)CD8alpha(+)CD45RA(-) dendritic cells. Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus.

• Authors: Christopher M Smith, Gabrielle T Belz, Nicholas S Wilson, Jose A Villadangos, Ken Shortman, Francis R Carbone, William R Heath
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 170 Issue 9 Pg. 4437-40 (May 01 2003) ISSN: 0022-1767 [Print] United States
• PMID: 12707318 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CD8 Antigens
• CD8alpha antigen
• Epitopes, T-Lymphocyte
• Histocompatibility Antigens Class I
• Immunodominant Epitopes
• Viral Envelope Proteins
• glycoprotein B, Simplexvirus

Topics

• Animals
• Antigen Presentation (immunology)
• Antigen-Presenting Cells (immunology, metabolism, virology)
• CD8 Antigens (biosynthesis)
• Cytotoxicity, Immunologic (immunology)
• Dendritic Cells (immunology, metabolism, virology)
• Epitopes, T-Lymphocyte (immunology, metabolism)
• Herpes Simplex (immunology, virology)
• Herpesvirus 1, Human (immunology)
• Hindlimb
• Histocompatibility Antigens Class I (metabolism)
• Hybridomas
• Immunity, Active
• Immunodominant Epitopes (immunology, metabolism)
• Injections, Subcutaneous
• Lymphocyte Activation (immunology)
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• T-Lymphocytes, Cytotoxic (immunology)
• Viral Envelope Proteins (immunology, metabolism)