Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells.

Abstract

CD8(+) effector T cells recognize malignant cells by monitoring their surface for the presence of tumor-derived peptides bound to MHC class I molecules. In addition, tumor-derived Ags can be cross-presented to CD8(+) effector T cells by APCs. IFN-gamma production by CD8(+) T cells is often critical for tumor rejection. However, it remained unclear whether 1) CD8(+) T cells secrete IFN-gamma in response to Ag recognition on tumor cells or APCs and 2) whether IFN-gamma mediates its antitumor effect by acting on host or tumor cells. We show in this study that CD8(+) effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-gammaR. Together, CD8(+) effector T cells recognize Ag directly on tumor cells, and this recognition is sufficient to reject tumors by IFN-gamma acting on host cells.

• Authors: Thomas Schüler, Thomas Blankenstein
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 170 Issue 9 Pg. 4427-31 (May 01 2003) ISSN: 0022-1767 [Print] United States
• PMID: 12707316 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• Receptors, Interferon
• interferon gamma receptor
• Interferon-gamma
• Ovalbumin

Topics

• Animals
• Antigen Presentation (immunology)
• Antigen-Presenting Cells (immunology, metabolism)
• Antigens, Neoplasm (immunology, metabolism)
• Bone Marrow Cells (immunology, metabolism)
• CD8-Positive T-Lymphocytes (immunology)
• Cells, Cultured
• Graft Rejection (immunology)
• Interferon-gamma (metabolism, physiology)
• Melanoma, Experimental (immunology, metabolism, prevention & control)
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Mice, Transgenic
• Neoplasm Transplantation
• Ovalbumin (immunology, metabolism)
• Receptors, Interferon (biosynthesis, physiology)
• Tumor Cells, Cultured