On the 4'-phosphopantetheine content of chicken and rat liver fatty acid synthetases.

Abstract

The finding that animal synthetases are complexes consisting of two polypeptide chains (Stoops, J.K., Arslanian, M.J., Oh, Y.H., Vanaman, T.C., and Wakil, S.J. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 1940-1944) led us to investigate their 4'-phosphopantetheine content. We have found that the chicken and rat synthetases contain 1.6 to 2.2 mol of 4'-phosphopantetheine per mol of the complex. The implications of this finding concerning the structure of the complex and the biosynthetic pathway of fatty acid synthesis are discussed.

• Authors: M J Arslanian, J K Stoops, Y H Oh, S J Wakil
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 251 Issue 10 Pg. 3194-6 (May 25 1976) ISSN: 0021-9258 [Print] United States
• PMID: 1270444 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Organophosphorus Compounds
• Sulfhydryl Compounds
• Taurine
• Pantetheine
• Fatty Acid Synthases
• Alanine

Topics

• Alanine (analysis)
• Animals
• Chickens
• Fatty Acid Synthases
• Liver (enzymology)
• Molecular Weight
• Organophosphorus Compounds (analysis)
• Pantetheine (analogs & derivatives, analysis)
• Rats
• Sulfhydryl Compounds (analogs & derivatives)
• Taurine (analysis)