Pharmacodynamics of isoflupredone acetate in an endotoxin-induced mastitis model.

Abstract

The effect of intravenous administration of the steroidal drug isoflupredone acetate on lactating dairy cows with mastitis induced using gram-negative bacterial endotoxin was investigated. Cows were randomly assigned to one of four treatment groups: untreated controls, isoflupredone acetate only, mastitis only, and mastitis plus isoflupredone acetate. Isoflupredone acetate was given to treated groups at a dose of 20 mg intravenously, once. Mastitic cows receiving treatment were given isoflupredone acetate after the development of clinical signs. When compared with untreated mastitic controls, cows with endotoxin-induced mastitis treated with isoflupredone acetate did not exhibit measurable differences in heart rate, rectal temperature, rumen motility, or changes in mammary gland surface area in the 14 h following the administration of intramammary endotoxin. Healthy cows treated with isoflupredone acetate had a higher heart rate over the 14 h after drug administration than did untreated healthy controls. When compared with untreated mastitic controls, cows treated with isoflupredone acetate did not exhibit statistically significant differences in milk production following endotoxin-induced mastitis.

• Authors: S A Wagner, M D Apley
• Journal: Journal of dairy science (J Dairy Sci) Vol. 86 Issue 3 Pg. 792-8 (Mar 2003) ISSN: 0022-0302 [Print] United States
• PMID: 12703615 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endotoxins
• isoflupredone acetate
• Fluprednisolone

Topics

• Animals
• Body Temperature
• Cattle
• Endotoxins
• Female
• Fluprednisolone (analogs & derivatives, pharmacology, therapeutic use)
• Heart Rate
• Kinetics
• Lactation
• Mammary Glands, Animal (pathology)
• Mastitis, Bovine (chemically induced, drug therapy, physiopathology)
• Muscle Contraction
• Rumen (physiopathology)