Is the combination of calcipotriol and PUVA effective in vitiligo?

Abstract

OBJECTIVE:

The objective was to compare the effectiveness of psoralen plus ultraviolet A (PUVA) and the combination of PUVA and topical calcipotriol in the treatment of vitiligo.

BACKGROUND:

There are several reports on the response rate of patients with vitiligo treated with the combination of PUVA and calcipotriol or calcipotriol alone.

SUBJECTS AND METHODS:

Twenty-two patients with generalized vitiligo were taken into the study. PUVA treatment was applied on a twice-weekly schedule. Calcipotriol cream was applied to one of the two symmetrical lesions of each patient twice daily.

RESULTS:

Our results showed that the addition of topical calcipotriol to PUVA treatment did not lead to a significant increase in response rate of patients with vitiligo compared with PUVA treatment alone.

• Authors: V Baysal, M Yildirim, A Erel, D Kesici
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 17 Issue 3 Pg. 299-302 (May 2003) ISSN: 0926-9959 [Print] England
• PMID: 12702070 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Dermatologic Agents
• calcipotriene
• Calcitriol

Topics

• Administration, Cutaneous
• Adolescent
• Adult
• Aged
• Calcitriol (administration & dosage, analogs & derivatives, therapeutic use)
• Combined Modality Therapy
• Dermatologic Agents (administration & dosage, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• PUVA Therapy
• Treatment Outcome
• Vitiligo (drug therapy, pathology)