Potentiation of ethanol narcosis by dopamine- and l-DOPA-based isoquinolines.

Abstract	The isoquinolines, salsolinol and 3-carboxysalsolinol, prolong ethanol-induced narcosis in mice. Pretreatment with carbidopa increases the effect of 3-carboxysalsolinol but not of salsolinol. These results suggest that ethanol sleeping-time potentiation by l-LOPA may involve a partial conversion to the isoquinoline in vivo. A central depressant action of salsolinol or the 3-carboxy analogue is suggested.
Authors	A Marshall, M Hirst
Journal	Experientia (Experientia) Vol. 32 Issue 2 Pg. 201-3 (Feb 15 1976) ISSN: 0014-4754 [Print] Switzerland
PMID	1269611 (Publication Type: Journal Article)
Chemical References	Alkaloids Isoquinolines Salsoline Alkaloids Ethanol Levodopa carboxysalsolinol Carbidopa Dopamine
Topics	Alkaloids (pharmacology) Animals Carbidopa (pharmacology) Dopamine (pharmacology) Drug Synergism Ethanol (pharmacology) Isoquinolines (pharmacology) Levodopa (pharmacology) Male Mice Salsoline Alkaloids Sleep (drug effects)

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