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Double sequential counterimmunoelectrophoresis (DCIEP): an improved method for detection of hepatitis-B antigen (HBAg).

Abstract
A method is described for increasing the sensitivity of conventional counterimmunoelectrophoresis (CIEP), i.e. double sequential counterimmunoelectrophoresis (DCIEP). Our method consists of a second electrophoretic migration made after the classical CIEP, where instead of HB antibody (from polytransfused patients), the anodic wells are filled with an antihuman-gammaglobulin antiserum. DCIEP is significantly more sensitive than CIEP (P less than 0.01), the number of positive sera in chronic lever diseases being 28.7% compared with 17.5%.
AuthorsO Abrudan, D Dejica
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 69 Issue 1 Pg. 113-5 (May 17 1976) ISSN: 0009-8981 [Print] Netherlands
PMID1269147 (Publication Type: Journal Article)
Chemical References
  • Hepatitis B Antigens
Topics
  • Chronic Disease
  • Counterimmunoelectrophoresis (methods)
  • Hepatitis B Antigens (analysis)
  • Humans
  • Liver Diseases (diagnosis, immunology)
  • Microchemistry

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