Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer.

Abstract

PURPOSE:

Kampo medicine Hangeshashin-to (TJ-14) which contains baicalin, a beta-glucuronidase inhibitor, alleviates diarrhea induced by irinotecan (CPT-11). We conducted a randomized comparative trial to investigate whether support with TJ-14 would prevent and control CPT-11-induced diarrhea.

METHODS:

Of 44 previously untreated patients with advanced non-small-cell lung cancer randomized, 41 (18 TJ-14 group, 23 control group) were available for evaluation. The chemotherapy regimen consisted of a combination of cisplatin and CPT-11. TJ-14 (7.5 g/day) was administered orally.

RESULTS:

Of the 41 patients, 39 experienced diarrhea. Compared with the control group, the TJ-14 group showed a significant improvement in diarrhea grades ( P=0.044) as well as a reduced frequency of diarrhea grades 3 and 4 (one patient versus ten patients; P=0.018). However, the two groups showed no differences in the frequency of diarrhea or the number of days the symptoms continued. This study was stopped at an interim evaluation.

CONCLUSION:

TJ-14 was effective in preventing and controlling CPT-11-induced diarrhea.

• Authors: Kiyoshi Mori, Tetsuro Kondo, Yukari Kamiyama, Yasuhiko Kano, Keigo Tominaga
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 51 Issue 5 Pg. 403-6 (May 2003) ISSN: 0344-5704 [Print] Germany
• PMID: 12687289 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• hange-shashinto
• Irinotecan
• Cisplatin
• Camptothecin

Topics

• Adult
• Aged
• Antineoplastic Agents, Phytogenic (adverse effects, therapeutic use)
• Camptothecin (adverse effects, analogs & derivatives, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy)
• Cisplatin (therapeutic use)
• Diarrhea (chemically induced, prevention & control)
• Drugs, Chinese Herbal (pharmacology)
• Female
• Humans
• Irinotecan
• Lung Neoplasms (drug therapy)
• Male
• Medicine, Kampo
• Middle Aged
• Treatment Outcome