[Pharmacological properties of 11-deoxymisoprostol].

Abstract

11-Deoxymisoprostol showed gastroprotector activity on the acute models of ulcers induced by acetylsalicylic acid and ethanol and produced curative effect on the chronic ulceration model induced by acetic acid. The positive effect is manifested by a decrease in the number of destructions and in the total area of chronic damage in the mucous membrane of the stomach. In addition, 11-deoxymisoprostol showed antiphlogistic activity on the acute edema models induced by carrageenan and formalin, by decreasing the model foot edema growth in experimental animals. The drug also decreased the level of lipid peroxidation in the rat blood serum on the background of acute ethanol ulceration.

• Authors: T A Sapozhnikova, F S Zarudiĭ, L T Karachurina, N S Makara, R Iu Khisamutdinova, A M Shaĭnurova, N A Ivanova, M S Miftakhov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2003 Jan-Feb Vol. 66 Issue 1 Pg. 34-6 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Farmakologicheskie svoĭstva 11-dezoksimizoprostola.
• PMID: 12683078 (Publication Type: English Abstract, Journal Article)

Chemical References

• 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Misoprostol
• Malondialdehyde

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Anti-Ulcer Agents (pharmacology)
• Edema (chemically induced, prevention & control)
• Female
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (blood)
• Mice
• Misoprostol (analogs & derivatives, pharmacology)
• Rats
• Stomach Ulcer (chemically induced, prevention & control)