| Abstract | The biggest challenge for host immune defense against mastitis-causing bacteria in dairy cows is to quickly recruit large enough numbers of opsonizing molecules and mature neutrophils into milk such that intramammary pathogens are cleared before they multiply significantly and the inflammatory response gets out of control. Currently, this challenge is best facilitated when established mastitis control procedures are practiced on the farm, including proper hygiene, milking procedures, and regular administration of approved mastitis vaccines. However, mastitis is still a significant problem. New animal functional genomics research is beginning to allow scientists to solve the puzzle of mastitis susceptibility. Results of this type of research offer the hope of giant leaps toward a clear identification of molecular genetic variation and potential gene targets for therapies and immune manipulations that could significantly reduce the risk of clinical mastitis in traditionally susceptible cows. |
| Authors | Jeanne L Burton, Ronald J Erskine
(Affiliation: Immunogenetics Laboratory, Department of Animal Science, Michigan State University, 1205E Anthony Hall, East Lansing, MI 48824, USA. burtonj at pilot.msu.edu)
|
| Journal | The Veterinary clinics of North America. Food animal practice
(Vet Clin North Am Food Anim Pract)
Vol. 19
Issue 1
Pg. 1-45, v
(Mar 2003)
ISSN: 0749-0720 United States |
| PMID | 12682934
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
|
| Topics |
- Animals
- Cattle
- Dairying
(methods)
- Disease Susceptibility
(veterinary)
- Female
- Mastitis, Bovine
(immunology, prevention & control)
- Neutrophils
(immunology, physiology)
- Phagocytosis
- Respiratory Burst
|
