Abstract | OBJECTIVE: METHODS: Fifteen pentobarbital anesthetized and mechanically ventilated dogs were randomized into three groups of five dogs each. One group served as an endotoxin alone, time matching group and, 1 hr after endotoxin administration, the two other groups received CVVH at 3 L/hr for 270 mins, with either a polysulphone membrane or an polyacrylonitrile membrane. RESULTS: At 90 mins after endotoxin administration, dogs receiving CVVH with polyacrylonitrile membranes had a higher cardiac output, stroke volume, and left-ventricular stroke work index than the endotoxin alone and the polysulphone groups. CVVH with either polyacrylonitrile or polysulphone membranes prevented the rise in pulmonary artery pressure and pulmonary vascular resistance compared with the endotoxin alone group. Plasma lactate levels were not significantly altered, but the fall in bicarbonate seen in the endotoxin alone group did not occur in the two CVVH groups. Tumor necrosis factor levels in the plasma were not significantly altered by CVVH and remained very low (<50 pg/mL) in the ultrafiltrate fluid. CONCLUSION:
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Authors | Peter Rogiers, Haibo Zhang, Dirk Pauwels, Jean-Louis Vincent |
Journal | Critical care medicine
(Crit Care Med)
Vol. 31
Issue 4
Pg. 1219-25
(Apr 2003)
ISSN: 0090-3493 [Print] United States |
PMID | 12682496
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acrylic Resins
- Bicarbonates
- Biocompatible Materials
- Endotoxins
- Membranes, Artificial
- Nitrates
- Nitrites
- Polymers
- Sulfones
- Tumor Necrosis Factor-alpha
- polyacrylonitrile
- polysulfone P 1700
- Lactic Acid
- endotoxin, Escherichia coli
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Topics |
- Acrylic Resins
- Animals
- Bicarbonates
(blood)
- Biocompatible Materials
- Dogs
- Endotoxins
- Escherichia coli
- Hemodynamics
- Hemofiltration
(instrumentation)
- Lactic Acid
(blood)
- Membranes, Artificial
- Nitrates
(blood)
- Nitrites
(blood)
- Polymers
- Shock, Septic
(blood, physiopathology, therapy)
- Sulfones
- Tumor Necrosis Factor-alpha
(analysis)
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