Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis.

Abstract

We examined the therapeutic effect of a 1% cream preparation of NND-502, a novel topical antifungal agent, in a guinea pig tinea pedis model produced by infecting the plantar skin of guinea pigs with Trichophyton mentagrophytes. Animals developing tinea pedis were divided into two groups: an untreated control group and a treated group. In the latter group, after confirming infection had been established, the infected animals were topically treated with the NND-502 cream once daily for one week. The animals were reared in a clean environment free from exposure to exogenous dermatophytes. At one week (5 weeks post-infection), 6 weeks (10 weeks post-infection) and 16 weeks (20 weeks post-infection) after completion of the treatment, plantar skin samples were taken from a certain number of both groups of animals. The results demonstrated that all of the animals in the untreated control group and none of those in the treated group were culture-positive in this animal model of tinea pedis. The topical treatment with NND-502 achieved a mycological cure. Thus NND-502 can be considered a promising candidate as a new anti-dermatophytic agent for topical use.

• Authors: Katsuhisa Uchida, Takashi Tanaka, Hideyo Yamaguchi
• Journal: Microbiology and immunology (Microbiol Immunol) Vol. 47 Issue 2 Pg. 143-6 ( 2003) ISSN: 0385-5600 [Print] Australia
• PMID: 12680717 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Culture Media
• Imidazoles
• luliconazole

Topics

• Administration, Topical
• Animals
• Antifungal Agents (therapeutic use)
• Culture Media
• Disease Models, Animal
• Female
• Guinea Pigs
• Imidazoles (therapeutic use)
• Skin (microbiology)
• Tinea Pedis (drug therapy, microbiology)
• Treatment Outcome
• Trichophyton (drug effects, growth & development, pathogenicity)