| Abstract | In this study, 50 cases of canine pemphigus foliaceus and 49 cases of canine superficial pyoderma were examined by immunohistochemical staining for patterns of desmoglein expression. In 31/50 (62%) of pemphigus foliaceus cases, there was an altered staining pattern for desmoglein consisting of distinct clumped deposits at the periphery of keratinocytes and/or dark cytoplasmic staining of acantholytic cells (consistent with internalization of desmoglein). In contrast, desmoglein staining in biopsies from cases of superficial pyoderma was diffusely pale without evidence for clumping or distinct internalization. This study demonstrates that epidermal desmoglein expression is altered in some cases of pemphigus foliaceus in dogs and suggests that immunohistochemical staining for this protein may be useful in diagnosis. |
| Authors | Elizabeth B Steeves, Brian J Chelack, Edward G Clark, Deborah M Haines
(Affiliation: Department of Veterinary Pathology, Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, 57N 5B4, Canada.)
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| Journal | Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
(J Vet Diagn Invest)
Vol. 14
Issue 1
Pg. 53-6
(Jan 2002)
ISSN: 1040-6387 United States |
| PMID | 12680644
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Cytoskeletal Proteins
- Desmogleins
- Desmoplakins
|
| Topics |
- Animals
- Biopsy
- Cytoskeletal Proteins
(analysis)
- Desmogleins
- Desmoplakins
- Dog Diseases
(metabolism, pathology)
- Dogs
- Gene Expression Regulation
- Immunohistochemistry
- Pemphigus
(metabolism, pathology, veterinary)
- Skin
(metabolism, pathology)
|
