Abstract |
The molecular events associated with the development of adenocarcinoma of the oesophagus are not well understood. Gene expression associated with oesophageal adenocarcinoma was investigated using a cDNA array containing 1,176 human cancer-associated genes. Approximately 59% of the genes were expressed at detectable levels with 15 genes (1.3%) exhibiting differential (> 2.5-fold) expression in either normal oesophagus or adenocarcinoma tissue. Nine genes were up-regulated in oesophageal adenocarcinoma tissue ( matrix metalloproteinase 11 (MMP11), ornithine decarboxylase (ODC), cytokeratins 8 and 18, integrin alpha 3 (ITGA3), integrin alpha 6 (ITGA6), BIGH3 ( transforming growth factor beta-induced), beta-catenin and CDC25B ( M-phase inducer phosphatase 2)). Six genes were down-regulated in adenocarcinoma tissue ( cytokeratin 4, plasminogen activator inhibitor 2 (PAI-2), interleukin 1 receptor antagonist (IRAP), cytokeratin 13/15/17, MAD and retinoic acid receptor gamma 1 (RARG)). Many of these differentially expressed genes influence cell-cell adhesion, cell-extracellular matrix and composition, transcriptional activation and cell cycle progression and are likely to contribute to development of oesophageal adenocarcinoma.
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Authors | R N Hourihan, G C O'Sullivan, J G Morgan |
Journal | Anticancer research
(Anticancer Res)
2003 Jan-Feb
Vol. 23
Issue 1A
Pg. 161-5
ISSN: 0250-7005 [Print] Greece |
PMID | 12680208
(Publication Type: Journal Article)
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Chemical References |
- CTNNB1 protein, human
- Cell Adhesion Molecules
- Cytoskeletal Proteins
- DNA Probes
- Extracellular Matrix Proteins
- IL1RN protein, human
- Interleukin 1 Receptor Antagonist Protein
- Intermediate Filament Proteins
- Neoplasm Proteins
- Sialoglycoproteins
- Trans-Activators
- Transforming Growth Factor beta
- beta Catenin
- betaIG-H3 protein
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Topics |
- Adenocarcinoma
(genetics, metabolism)
- Cell Adhesion Molecules
(biosynthesis, genetics)
- Cytoskeletal Proteins
(biosynthesis, genetics)
- DNA Probes
- Esophageal Neoplasms
(genetics, metabolism)
- Esophagus
(metabolism, pathology)
- Extracellular Matrix Proteins
- Gene Expression Profiling
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Intermediate Filament Proteins
(biosynthesis, genetics)
- Multigene Family
- Neoplasm Proteins
(biosynthesis, genetics)
- Reproducibility of Results
- Reverse Transcriptase Polymerase Chain Reaction
- Sialoglycoproteins
(biosynthesis, genetics)
- Trans-Activators
(biosynthesis, genetics)
- Transcription, Genetic
- Transforming Growth Factor beta
- beta Catenin
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