Physico-chemical and medico-
biological methods, including hematology and cytology, were used in an evaluation of properties of poly(2-hydroxyethyl methacrylate) (
poly(HEMA))-based embolic material indicated in the occlusion of branches of hepatic artery of patients with focal alterations of the liver. The elastographic method helped in predicting mechanical properties of the
hydrogel material.
Poly(HEMA) was mechanically stable for endovascular applications, exhibited no significant loss in elasticity and possessed consistency resembling the soft tissue of the organism. Analysis of blood in contact with
poly(HEMA)
hydrogel provided a control of its
biological inertness. Recently, 315 patients with focal alterations of the liver, including hemobilic
hemorrhages and both primary and metastatic
tumors, underwent endovascular occlusion with
poly(HEMA) emboli as a pre-surgical step or as a simple occlusive measure. Compared with a direct operation on hemangiomatous
injuries in the liver without endovascular occlusion, embolization with
poly(HEMA) allowed to reduce 2.5-3 times bleeding in the operational zone. At the same time, the
poly(HEMA) embolic material induced activation of general
hemostatic reaction in the postembolization period.