Significant reduction in the incidence of phlebitis with buffered versus unbuffered cephalothin.

Abstract

Cephalothin (1 g every 2 h), buffered cephalothin, and diluent alone (5% dextrose in water) were each administered for 4 days intravenously to 12 volunteers in a double-blind crossover study. The incidence of phlebitis with buffered cephalothin was significantly lower than that with unbuffered drug (P < 0.01) and almost identical to the incidence with diluent alone.

• Authors: M G Bergeron, J L Brusch, M Barza, L Weinstein
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 9 Issue 4 Pg. 646-8 (Apr 1976) ISSN: 0066-4804 [Print] United States
• PMID: 1267438 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Buffers
• Glucose
• Cephalothin

Topics

• Adult
• Buffers
• Cephalothin (adverse effects)
• Glucose (adverse effects)
• Humans
• Male
• Phlebitis (chemically induced)