Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix.

Abstract

An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been synthesized and evaluated as an inhibitor of neural tumor growth. The glycoside inhibited the growth of a neuroectodermic tumor implanted in rats and, when loaded on a slow-delivery polymer disk, caused the destruction of cultured human astroblastoma obtained after surgical biopsy.

• Authors: Alfonso Fernández-Mayoralas, Natalia De La Figuera, Mercedes Zurita, Jesús Vaquero, Gustavo A Abraham, Julio San Román, Manuel Nieto-Sampedro
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 46 Issue 8 Pg. 1286-8 (Apr 10 2003) ISSN: 0022-2623 [Print] United States
• PMID: 12672228 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-acetamido-2-deoxy-6-O-(2,2-bis(hydroxymethyl)-3-hydroxypropyl)glucopyranoside
• Antineoplastic Agents
• Delayed-Action Preparations
• Drug Carriers
• Glycosides
• Polymers
• Propylene Glycols
• Acetylglucosamine

Topics

• Acetylglucosamine (analogs & derivatives, chemical synthesis, pharmacology)
• Animals
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Brain Neoplasms (chemically induced, drug therapy, pathology)
• Delayed-Action Preparations
• Drug Carriers
• Female
• Glycosides (chemical synthesis, pharmacology)
• Humans
• Male
• Neoplasm Transplantation
• Neoplasms, Neuroepithelial (pathology)
• Neuroectodermal Tumors, Primitive (chemically induced, drug therapy, pathology)
• Polymers
• Propylene Glycols (chemical synthesis, pharmacology)
• Rats
• Rats, Wistar
• Tumor Cells, Cultured