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A molecular warhead and its target: tissue transglutaminase and Celiac Sprue.

Abstract
The substitution of a glutamine residue with 6-diazo-5-oxo-norleucine (DON) transforms an immunodominant gluten peptide into a potent inhibitor of tissue transglutaminase. DON-modified peptides could be useful for the study and therapy of celiac sprue.
AuthorsDetlef Schuppan, Walburga Dieterich
JournalChemistry & biology (Chem Biol) Vol. 10 Issue 3 Pg. 199-201 (Mar 2003) ISSN: 1074-5521 [Print] United States
PMID12670530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Comment)
Chemical References
  • Peptides
  • Diazooxonorleucine
  • Glutamine
  • Glutens
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases
  • GTP-Binding Proteins
Topics
  • Celiac Disease (drug therapy, enzymology)
  • Diazooxonorleucine (analogs & derivatives, chemical synthesis, pharmacology)
  • GTP-Binding Proteins (antagonists & inhibitors)
  • Glutamine (chemistry)
  • Glutens (chemistry)
  • Humans
  • Peptides (chemical synthesis, chemistry, pharmacology)
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases (antagonists & inhibitors)

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