G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy.

Abstract

A common polymorphism (C825T) of the gene encoding the G-protein beta(3) subunit has been associated with obesity. We examined the hypothesis that this polymorphism affected weight gain during pregnancy. Two hundred and ninety-four women with uncomplicated term deliveries of singleton pregnancies were genotyped. Women homozygous for the T allele (TT) gained significantly more weight than women carrying the C allele (CC and CT groups) (P = 0.006) and had a significantly higher pre-pregnancy body mass index (P = 0.02). The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.

• Authors: Victor Dishy, Simi Gupta, Ruth Landau, Hong-Guang Xie, Richard B Kim, Richard M Smiley, Daniel W Byrne, Alastair J J Wood, C Michael Stein
• Journal: Pharmacogenetics (Pharmacogenetics) Vol. 13 Issue 4 Pg. 241-2 (Apr 2003) ISSN: 0960-314X [Print] England
• PMID: 12668921 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• G-protein beta3 subunit
• Heterotrimeric GTP-Binding Proteins

Topics

• Adult
• Birth Weight
• Female
• Heterotrimeric GTP-Binding Proteins (genetics)
• Humans
• Infant, Newborn
• Polymorphism, Single Nucleotide
• Pregnancy (genetics, physiology)
• Weight Gain (genetics)