Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester.

Abstract

We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.

• Authors: Muhieddine Seoud, Anwar Nassar, Ihab Usta, Mohammad Mansour, Ibrahim Salti, Khaled Younes
• Journal: American journal of perinatology (Am J Perinatol) Vol. 20 Issue 2 Pg. 59-62 (Feb 2003) ISSN: 0735-1631 [Print] United States
• PMID: 12660909 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antithyroid Agents
• Methimazole

Topics

• Abnormalities, Multiple (chemically induced, etiology)
• Adolescent
• Adult
• Antithyroid Agents (administration & dosage, adverse effects)
• Biliary Atresia (chemically induced, etiology, surgery)
• Digestive System (drug effects)
• Digestive System Abnormalities
• Esophageal Atresia (chemically induced, etiology, surgery)
• Female
• Humans
• Hyperthyroidism (complications, drug therapy)
• Infant, Newborn
• Methimazole (administration & dosage, adverse effects)
• Pregnancy
• Pregnancy Complications (drug therapy)
• Time Factors
• Tracheoesophageal Fistula (chemically induced, etiology, surgery)
• Treatment Outcome