Abstract | BACKGROUND: METHODS: We made a case note review of 19 children who received OK-432 injection. Median duration of follow-up was 17 months. RESULTS: Lesions were diagnosed antenatally in 4 children, at birth in 4 children, and between 1 month and 11 years in the remainder. Anatomic locations were head/neck in 14, axilla in 1, and multiple locations in 4. Median number of injections per child was 2 (range, 1 to 5). Disappearance of the lesion was achieved after OK-432 injection in 2 patients (11%) and a marked reduction in 5 (26%); all these lesions were in the head and neck. Lesions larger than 5 cm and those outside the head and neck region did not respond well to OK-432 injection. Fourteen children (74%) required surgical excision after injection. Complications of OK-432 injection included partial tracheal obstruction, fever, local inflammatory response, and abscess formation. CONCLUSIONS:
OK-432 injection was effective in approximately one third of children with lymphangioma. Lesions outside the head and neck and those larger than 5 cm are unlikely to respond to this therapy. Injection of lymphangioma surrounding the airways may be hazardous.
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Authors | Nigel Hall, Niyi Ade-Ajayi, Clive Brewis, Derek J Roebuck, Edward M Kiely, David P Drake, Lewis Spitz, Agostino Pierro |
Journal | Surgery
(Surgery)
Vol. 133
Issue 3
Pg. 238-42
(Mar 2003)
ISSN: 0039-6060 [Print] United States |
PMID | 12660633
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Picibanil
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Topics |
- Antineoplastic Agents
(administration & dosage)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Infant
- Infant, Newborn
- Injections, Intralesional
- Lymphangioma
(drug therapy, surgery)
- Male
- Picibanil
(administration & dosage)
- Treatment Outcome
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