Expression of c-erbB2 in gestational trophoblastic disease and its clinical significance.

Abstract

In order to explore a potential indicator of predicting the occurrence and development of gestational trophoblastic tumor, the expression of c-erbB2 oncogene in human normal placenta, hydatidiform mole and choriocarcinoma was investigated. The expression of c-erbB2 was detected immunohistochemically by monoclonal antibody against the gene on the formalin-fixed paraffin sections of 21 hydatidiform moles, 21 invasive moles, 20 choriocarcinomas and 30 normal placentas. Results showed that the expression level of c-erbB2 was significantly higher in gestational trophoblastic tumor than in hydatidiform mole and normal placenta of midterm and term pregnancy (P < 0.05), while there was no significant difference between patients with gestational trophoblastic tumor of stage III, IV and those of stage I, II. It was demonstrated that overexpression of c-erbB2 may closely associated with malignant transformation of hydatidiform mole, not only providing important insight into pathogenesis of gestational trophoblastic tumor, but also having an important significance for the early diagnosis and early treatment of gestational trophoblastic tumor.

• Authors: Yuxia Wang, Yang Cao, Yongyu Sun
• Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 22 Issue 2 Pg. 123-5 ( 2002) ISSN: 1672-0733 [Print] China
• PMID: 12658752 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Receptor, ErbB-2

Topics

• Biomarkers, Tumor
• Choriocarcinoma (metabolism)
• Female
• Genes, erbB-2
• Humans
• Hydatidiform Mole (metabolism)
• Hydatidiform Mole, Invasive (metabolism)
• Placenta (metabolism)
• Pregnancy
• Receptor, ErbB-2 (biosynthesis, genetics)
• Uterine Neoplasms (metabolism)