Abstract | BACKGROUND: METHODS:
Myocardial infarction was created in pigs by means of occlusion of the first and second obtuse marginal branches of the circumflex coronary artery, resulting in a uniform left ventricular free wall infarct size of 21% +/- 2%. At 5 days after infarction, the pigs were randomized to undergo broad-spectrum matrix metalloproteinase inhibition (n = 9; PD166793, 20 mg. kg(-1). d(-1) by mouth) or myocardial infarction alone (n = 8). Ten pigs served as noninfarction control animals. Left ventricular end-diastolic area, determined by means of echocardiography, was measured 8 weeks after infarction. RESULTS: CONCLUSIONS:
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Authors | William M Yarbrough, Rupak Mukherjee, Theresa A Brinsa, Kathryn B Dowdy, Amelia A Scott, G Patricia Escobar, Cassandra Joffs, David G Lucas, Fred A Crawford Jr, Francis G Spinale |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 125
Issue 3
Pg. 602-10
(Mar 2003)
ISSN: 0022-5223 [Print] United States |
PMID | 12658202
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- (R)-2-(4'-bromo-biphenyl-4-sulfonyl-amino)-3-methyl-butyric acid
- Hydroxamic Acids
- Matrix Metalloproteinase Inhibitors
- Oligopeptides
- Tissue Inhibitor of Metalloproteinases
- Matrix Metalloproteinases
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Topics |
- Analysis of Variance
- Animals
- Disease Models, Animal
- Disease Progression
- Drug Evaluation, Preclinical
- Echocardiography, Transesophageal
- Hemodynamics
(drug effects)
- Hydroxamic Acids
(pharmacology, therapeutic use)
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(physiology)
- Myocardial Infarction
(complications, diagnosis, drug therapy, enzymology)
- Oligopeptides
(pharmacology, therapeutic use)
- Random Allocation
- Stroke Volume
(drug effects)
- Swine
- Time Factors
- Tissue Inhibitor of Metalloproteinases
(pharmacology, therapeutic use)
- Ventricular Dysfunction, Left
(etiology, prevention & control)
- Ventricular Pressure
(drug effects)
- Ventricular Remodeling
(drug effects)
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