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Oxcarbazepine in the treatment of childhood epilepsy.

Abstract
In this study, oxcarbazepine was began as monotherapy to evaluate the efficacy and safety of the drug. Forty-two patients (19 females, 23 males) with partial or generalized epilepsy more than 4 years of age were included (mean age, 11.9 +/- 3.4 years). The mean age at epilepsy onset 8.9 +/- 4 years. Complete blood count, liver function tests, electrolytes, lipid levels, electrocardiography, electroencephalography, and magnetic resonance imaging were performed in all patients. Oxcarbazepine dose was begun at 10 mg/kg/day twice daily and increased to 30 mg/kg/day at the end of the second week. Patients with inadequate seizure control even with the dose of 45 mg/kg/day or intolerable side effects were excluded. Intolerable headache and leukopenia led to discontinuation of the drug in two patients. At the sixth month, 35 of the patients (87.5%) were seizure free (91.7% of the generalized epilepsy patients and 81.2% of the partial epilepsy patients). The most frequent tolerable side effect was drowsiness in 12 patients. As a result, we found oxcarbazepine safe and effective in children with either generalized or partial epilepsy.
AuthorsGul Serdaroglu, Semra Kurul, Sarenur Tutuncuoglu, Eray Dirik, Berrak Sarioglu
JournalPediatric neurology (Pediatr Neurol) Vol. 28 Issue 1 Pg. 37-41 (Jan 2003) ISSN: 0887-8994 [Print] United States
PMID12657418 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
Chemical References
  • Anticonvulsants
  • Carbamazepine
  • Oxcarbazepine
Topics
  • Adolescent
  • Anticonvulsants (administration & dosage, adverse effects)
  • Carbamazepine (administration & dosage, adverse effects, analogs & derivatives)
  • Child
  • Child, Preschool
  • Disease-Free Survival
  • Epilepsies, Partial (drug therapy)
  • Epilepsy, Generalized (drug therapy)
  • Female
  • Humans
  • Male
  • Oxcarbazepine
  • Treatment Outcome

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