[Effect of glycyrrhizin on anti-tuberculosis drug-induced hepatitis].

Abstract

In cases in which hepatotoxicity developed during anti-tuberculosis chemotherapy, the rapid recovery of liver function is essential for the completion of the anti-tuberculosis chemotherapy protocol. Glycyrrhizin (Stronger Neo-Minophagen C: SNMC) is widely used in Japan for the treatment of patients with drug eruption or chronic hepatitis. However, a consensus on the clinical effects of glycyrrhizin for the treatment of anti-tuberculosis drug-induced hepatitis has not yet been reached. We studied 24 cases who showed abnormal liver function test results while undergoing anti-tuberculosis chemotherapy and who were treated with or without glycyrrhizin. We then compared recovery periods of liver function among both groups. The time required for liver function normalization in the patients who received glycyrrhizin (SNMC, 40 ml daily, intravenously) was 15.1 +/- 4.5 days and the time required for normalization in the non-glycyrrhizin group was 15.2 +/- 5.2 days. The difference was not significant and the fact indicated that glycyrrhizin is not useful for the treatment of anti-tuberculosis drug-induced hepatitis.

• Authors: Naoki Miyazawa, Hiroshi Takahashi, Yasuhiro Yoshiike, Takashi Ogura, Yuji Watanuki, Masamichi Sato, Nobumasa Kakemizu, Yasushi Yamakawa, Chol-han U, Hideto Goto, Shigeki Odagiri
• Journal: Kekkaku : [Tuberculosis] (Kekkaku) Vol. 78 Issue 1 Pg. 15-9 (Jan 2003) ISSN: 0022-9776 [Print] Japan
• PMID: 12655701 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antitubercular Agents
• Glycyrrhizic Acid

Topics

• Adult
• Aged
• Antitubercular Agents (adverse effects)
• Chemical and Drug Induced Liver Injury (drug therapy, etiology)
• Glycyrrhizic Acid (therapeutic use)
• Humans
• Middle Aged
• Treatment Outcome