Abstract | BACKGROUND: Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear. DESIGN: The aim of the study was to determine endothelial function in patients with SCF using a flow-mediated dilatation (FMD) technique in the brachial artery. METHODS: Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count ( CTFC) method. Endothelial function was studied in 27 patients with SCF (23 men, four women, mean age 47.6+/-8.7 years) and in 30 people with normal coronary flow (NCF) (22 men and eight women, mean age 47.5+/-7.4 years). RESULTS: The flow-mediated diameter increase in the SCF group was significantly smaller than that in the NCF group (3.48+/-0.10% compared with 9.11+/-0.10%, P < 0.001). The percentage of nitroglycerine (NTG)-induced dilatation was not significantly different between patients with SCF and people with NCF (16.8+/-1.1% compared with 17.1+/-1.1%, P = 0.87). Simple regression analysis showed that mean CTFC ( CTFC(m)) was strongly and inversely related to the percentage of FMD (r = -0.29, P < 0.01) in all participants. When the patients with SCF were excluded, CTFC(m) was still inversely related to the percentage of FMD (r = -0.36, P < 0.05). CTFC(m) was also inversely related to NTG-induced dilatation in the 57 participants (r = -0.23, P < 0.05). Multiple regression analysis showed that CTFC(m) was inversely related to the percentage of FMD only (r = -0.37, P < 0.05). CONCLUSIONS: These findings suggest that endothelial function is impaired in people with SCF and that CTFC correlates well with endothelial dysfunction.
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Authors | Alpay Turan Sezgin, Ahmet Sigirci, Irfan Barutcu, Ergün Topal, Nurzen Sezgin, Ramazan Ozdemir, Ertan Yetkin, Izzet Tandogan, Feridun Kosar, Necip Ermis, Saim Yologlu, Emrah Bariskaner, Sengul Cehreli |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 14
Issue 2
Pg. 155-61
(Apr 2003)
ISSN: 0954-6928 [Print] England |
PMID | 12655279
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Vasodilator Agents
- Nitroglycerin
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Topics |
- Adult
- Blood Flow Velocity
(physiology)
- Brachial Artery
(drug effects, physiopathology)
- Coronary Angiography
- Coronary Artery Disease
(drug therapy, physiopathology)
- Coronary Circulation
(physiology)
- Coronary Thrombosis
(drug therapy, physiopathology)
- Endothelium, Vascular
(physiopathology)
- Female
- Humans
- Hyperemia
(drug therapy, physiopathology)
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy, physiopathology)
- Nitroglycerin
(therapeutic use)
- Statistics as Topic
- Turkey
- Vasodilation
(drug effects, physiology)
- Vasodilator Agents
(therapeutic use)
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