Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus-induced encephalitis.

Abstract	Immunization via the oral route with an attenuated Yersinia enterocolitica strain expressing a fragment of the measles virus nucleocapsid protein (aa 79-161) via its type III protein secretion system induced a T helper type 1 response in immunized C3H mice, which conferred protection against measles virus-induced encephalitis in a time- and dose-dependent manner.
Authors	Iris Gundel, Gerald Weidinger, Volker Ter Meulen, Jürgen Heesemann, Holger Rüssmann, Stefan Niewiesk
Journal	The Journal of general virology (J Gen Virol) Vol. 84 Issue Pt 4 Pg. 775-779 (Apr 2003) ISSN: 0022-1317 [Print] England
PMID	12655077 (Publication Type: Comparative Study, Journal Article)
Chemical References	Antigens, Differentiation, T-Lymphocyte Epitopes, T-Lymphocyte Measles Vaccine Nucleocapsid Proteins Vaccines, Synthetic
Topics	Administration, Oral Animals Antigens, Differentiation, T-Lymphocyte (genetics, immunology) Disease Models, Animal Dose-Response Relationship, Immunologic Encephalitis, Viral (prevention & control) Epitopes, T-Lymphocyte (administration & dosage, biosynthesis, genetics) Genetic Vectors Measles (immunology, prevention & control) Measles Vaccine (administration & dosage, genetics) Mice Mice, Inbred C3H Morbillivirus (immunology) Nucleocapsid Proteins (biosynthesis, genetics) T-Lymphocytes, Helper-Inducer (immunology) Time Factors Vaccination Vaccines, Synthetic (administration & dosage) Yersinia enterocolitica (metabolism)

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