P53 expression in spontaneous and estradiol-induced endometrial hyperplasia during menopause.

Abstract

OBJECTIVE:

To determine the percentage of endometrial hyperplasia positive for p53 expression in both spontaneously occurring cases or following the use of unopposed estradiol.

METHODS:

Fifty-four postmenopausal patients with endometrial hyperplasia diagnosed by endometrial biopsy and hysteroscopy were recruited to this study. Thirty-three patients had used unopposed estradiol for periods of time from 1 to 3 years. P53 expression was detected in paraffin-embedded endometrial specimens by immunohistochemical methods.

RESULTS:

The percentage of endometrial hyperplasia positive for p53 expression was significantly greater in spontaneously occurring hyperplasia than in cases induced by the unopposed use of estradiol.

CONCLUSION:

Endometrial hyperplasia caused by the unopposed use of estradiol during menopause probably harbors fewer genomic errors than those cases occurring spontaneously.

• Authors: Hugo Maia Jr, Amélia Maltez, Célia Athayde, Genevieve Coelho, Elsimar M Coutinho
• Journal: Maturitas (Maturitas) Vol. 44 Issue 3 Pg. 175-80 (Mar 28 2003) ISSN: 0378-5122 [Print] Ireland
• PMID: 12648880 (Publication Type: Journal Article)

Chemical References

• Tumor Suppressor Protein p53
• Estradiol

Topics

• Aged
• Aged, 80 and over
• Case-Control Studies
• Endometrial Hyperplasia (metabolism)
• Endometrium (chemistry)
• Estradiol (pharmacology, therapeutic use)
• Estrogen Replacement Therapy
• Female
• Humans
• Menopause (metabolism)
• Middle Aged
• Tumor Suppressor Protein p53 (metabolism)