Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens.

Abstract

Kuwanon G was isolated from the ethyl acetate fraction of methanol extract of Morus alba and its structure was elucidated by 13C-NMR, 1H-NMR and FAB-MS. Antibacterial activity of kuwanon G was investigated by the minimum inhibitory concentration (MIC) test and the viable cell count method. MIC of kuwanon G against Streptococcus mutans causing dental caries was determined to be 8.0 microg/ml. The bactericidal test showed that kuwanon G completely inactivated S. mutans at the concentration 20 microg/ml in 1 min. Kuwanon G also significantly inhibited the growth of other cariogenic bacteria such as Streptococcus sobrinus and Streptococcus sanguis, and Porpyromonas gingivalis causing periodontitis. Transmission electron microscopy (TEM) of kuwanon G treated cells demonstrated remarkable morphological damage of the cell wall and condensation of the cytoplasm.

• Authors: K M Park, J S You, H Y Lee, N I Baek, J K Hwang
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 84 Issue 2-3 Pg. 181-5 (Feb 2003) ISSN: 0378-8741 [Print] Ireland
• PMID: 12648813 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Elsevier Science Ireland Ltd.

Chemical References

• Anti-Bacterial Agents
• Flavonoids
• Solvents
• kuwanon G

Topics

• Anti-Bacterial Agents (isolation & purification, pharmacology)
• Bacteria (drug effects, ultrastructure)
• Colony Count, Microbial
• Flavonoids (isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Microbial Sensitivity Tests
• Microscopy, Electron
• Morus (chemistry)
• Plant Bark (chemistry)
• Plant Roots (chemistry)
• Solvents