Antiviral flavonoids from the root bark of Morus alba L.

Abstract

A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods.

• Authors: Jiang Du, Zhen-Dan He, Ren-Wang Jiang, Wen-Cai Ye, Hong-Xi Xu, Paul Pui-Hay But
• Journal: Phytochemistry (Phytochemistry) Vol. 62 Issue 8 Pg. 1235-8 (Apr 2003) ISSN: 0031-9422 [Print] England
• PMID: 12648543 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 Elsevier Science Ltd.

Chemical References

• Antiviral Agents
• Flavonoids
• Acyclovir

Topics

• Acyclovir (pharmacology)
• Animals
• Antiviral Agents (chemistry, pharmacology)
• Chlorocebus aethiops
• Flavonoids (chemistry, pharmacology)
• Herpesvirus 1, Human (drug effects)
• Inhibitory Concentration 50
• Microbial Sensitivity Tests (methods)
• Morus (chemistry)
• Plant Bark (chemistry)
• Plant Roots (chemistry)
• Plants, Medicinal (chemistry)
• Vero Cells